Upcycle: Brain & Body | Alfonso Alfini, PhD, MS | Substack

Upcycle: Brain & Body

Transforming knowledge into power, and setbacks into strength.

By Alfonso Alfini

· Launched a year ago

A Force of Nature

A Tribute to Cheryl Alfini

Jun 23•Alfonso Alfini, PhD, MS

Shouldn’t We All Be Training Like Elite Athletes?

Why Aging Requires Preparation, Not Reaction

Feb 2•Jennifer Guida, PhD, MPH and Alfonso Alfini, PhD, MS

The Science of Whenning

Why Timing Matters: Sleep, Diet, and Physical Activity

Nov 20, 2025•Alfonso Alfini, PhD, MS

What 30 Years of Discovery Teach Us About Protecting the Brain

Unfolding the Tangled Narrative

Nov 7, 2025•Alfonso Alfini, PhD, MS

The Case for Muscle-Driven Brain Health

He was a neuroscientist who spent his career studying the brain, writing grants late into the night, chasing the biology of memory while neglecting his…

Oct 23, 2025•Alfonso Alfini, PhD, MS

Part 3. Why Sleep Matters: How to Sleep Better

Unlocking the Night’s Hidden Dividend

Oct 6, 2025•Alfonso Alfini, PhD, MS

Part 2. Why Sleep Matters: The Costs of Lost Sleep

How Cutting Corners Speeds Up Aging and Reduces Resilience, What Hustle Culture Gets Wrong, and the Impact on America’s Youth

Oct 6, 2025•Alfonso Alfini, PhD, MS and Jennifer Guida, PhD, MPH

Reframing the POINTER Study Through a Precision Medicine Lens

Towards Smarter, Stronger, and More Personalized Approaches to Combat Cognitive Decline

Jul 31, 2025•Alfonso Alfini, PhD, MS